doi: 10.1525/bio.2010.60.1.6
The Evolution of Gene Regulatory Interactions
David A. Garfield and Gregory A. Wray
Abstract
Changes in the timing and level at which genes are expressed are known to play an important role in evolution, but the mechanisms underlying changes in gene expression remain relatively obscure. Until quite recently, evolutionary biologists, like most biologists, tended to study single genes as isolated entities. These studies have added enormously to our understanding of biological evolution. But because gene regulation by its very nature involves interactions between two (or more) genes, researchers have missed a range of evolutionary phenomena that can be observed only at the level of networks of interacting genes. In this article, we consider the change in perspective that genomic technologies—particularly the advent of largescale platforms for DNA sequencing, genotyping, and measuring gene expression—are bringing to evolutionary biology. We focus specifically on how these technologies can and are being used to increase our understanding of how and why gene expression evolves.
Keywords: evolution, gene networks, genomics, gene expression, gene regulation
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EXCERPT/EXCERTO:
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EXCERPT/EXCERTO:
"Taken together, these findings presented researchers with a paradox. On one hand, the basic machinery underlying early development, such as the Hox genes, is widely conserved among divergent phyla. But at the same time, these genes also underlie the development of distinct morphologies between more closely related species. The resolution of this “Hox paradox” is that the general role of many genes in patterning the embryo has been preserved, but the precise pattern of their expression or their influence on later events of development have both changed. These modifications are possible only through changes in regulatory interactions, whether mediated through changes in protein or nucleic acid sequences."
Eu achei a resolução deles muito vaga, o que você acha???
